Endocrine Abstracts

Aim: Dopamine agonist (DA) therapy is recommended as first-line treatment for prolactinomas, albeit with long treatment duration and high recurrence rate after treatment withdrawal. The aim of this retrospective study was to evaluate predictors for successful DA withdrawal.Methods: The study included 59 prolactinoma patients (39 female, 20 male; age 34 (18–82) years) that were treated with DA (35.6% on cabergoline); the duration of treatment was 71 ...

The role of systemic inflammation in promoting tumor progression has been a topic of increasing interest. Neutrophil-lymphocyte ratio (NLR) >5 and platelet-lymphocyte ratio (PLR) >190 used as indicators of inflammation have been reported to have prognostic value in numerous solid tumors. The aim of this retrospective study was to investigate NLR and PLR as biomarkers in distinguishing between adrenocortical adenomas and adrenocortical carcinomas (ACC). Nineteen patient...

Introduction: Cushing’s disease (CD) is an uncommon condition of excess endogenous glucocorticoids caused by ACTH secreting pituitary corticotroph adenoma. The purpose of this study is to review therapeutic outcomes and comorbidity of patients with CD in a single centre.Methods: We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014. (27 female and six male, median age 38 years...

Introduction: Isotretinoin (Iso) treatment in acne disease may cause dyslipidemia and increased liver enzymes. Its effects on lipid and glucose metabolism may cause atherogenic complications. The aim of this study was to evaluate carotis intima–media thickness (CIMT), HOMA-IR, and osteopontin (OPN) levels in acne patients on Iso treatment.Methods: Iso treatment given 21 patients are included in this study. They followed for 4 months. 21 patients wit...

Introduction: Whether subclinical hypothyroidism (SCH) is related to risk for cardiovascular disease is controversial. Inflammation and oxidation of lipoproteins play an important role in the progression and complications of atherosclerosis.Therefore we aimed to evaluate the plasma levels of thiobarbituric acid reactive substances (TBARS) as a marker of oxidative stress, high sensitive CRP (hsCRP) and lipid profile as a risk factor for atherosclerosis in...

Empty sella is characterized by the radiological appearance of an enlarged or deformed sella turcica which is completely or partially filled with cerebrospinal fluid resulting in a displacement of the normal pituitary gland. Primary empty sella (PES) refers to the empty sella appearance of unknown etiology, diagnosed after excluding a history of previous pituitary pathology. The prevalence of hypopituitarism in empty sella syndrome varies between 2 and 32% in different publish...

Objective: This study aimed to investigate the diagnostic performance of 18F-choline PET/CT in patients with negative or inconclusive results of 99mTc-sestamibi SPECT/CT in locating hyperfunctioning parathyroid tissue in primary hyperparathyroidism patients.Methods: We conducted a retrospective study involving patients who were operated on due to primary hyperparathyroidism from April 2019 to March 2022. The analysis focused on pati...

Background: Systematic or randomised studies on the natural course of non-functioning pituitary macroadenomas after surgery (NFPA) are lacking.Objectives: This study aimed to evaluate the long-term outcomes of residual NFPA following pituitary surgery.Methods: In this retrospective study, we included 130 patients with NPFA who underwent pituitary surgery between 2005 and 2018 at University Hospital Centre Zagreb. The median age of ...

Recognizing the site of origin of craniopharyngioma (CP) along the hypothalamus-pituitary axis according to pre-operative MR is helpful to understand its growth pattern in relation to hypothalamus, which is critical in the prediction of hypothalamic injury and planning of treatment. We retrospectively classified 29 CP according to MR pre-operative image study using modified classification of Tang et al. (Nature, 8:10215, 2018). According to its relation to pituitary s...

Background: The aim of this study was to evaluate the outcomes of medical treatment in patients with active acromegaly.Material and Methods: We performed a retrospective analysis of 163 patients (101 female, age at diagnosis 47.2±13.4 years) treated between 1990 and 2020., of which 53 were on medical treatment (32.5%). Remission rate after pituitary surgery was 66.5% (n=105/158; 5 patients refused surgery). Patients who did not achieve remiss...